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Writer's pictureJim Jones

Does Cannabis Affect Your Immune System?

Updated: Oct 16

Have you ever stopped to consider what cannabis does to your immune system? You might find the answer intriguing, especially for cannabis users. We’ve written this article, and others like it, so you can know more about the effects of cannabis and get rid of the common misconceptions about marijuana.


Introduction

Cannabis has been a topic of much debate and research, especially when it comes to its effects on the immune system. With the increasing legalization and use of cannabis for both medicinal and recreational purposes, understanding its impact on our body’s defense mechanisms has never been more crucial. This article delves into the intricate relationship between cannabis and the immune system, shedding light on both the potential benefits and risks. Cannabis Affect Your Immune System


What is the Immune System and How Does it Work? Cannabis Affect Your Immune System

The immune system is a complex network of cells, tissues, and organs that work together to defend the body against foreign invaders like bacteria, viruses, and other pathogens. Think of it as your body’s personal security team, always on the lookout for anything that doesn’t belong. This vital system is divided into two main branches: the innate immune system and the adaptive immune system.


The innate immune system is your first line of defense, providing immediate but non-specific protection against invaders. It’s like the security guards at the entrance of a building, stopping anything suspicious from getting in. On the other hand, the adaptive immune system is more specialized. It takes a bit longer to kick in but provides long-term immunity by producing antibodies and immune cells tailored to specific threats. This is akin to a specialized task force that remembers past intruders and knows exactly how to deal with them if they show up again.


The Endocannabinoid System

The sites in the brain and body where cannabis is absorbed are called cannabinoid receptors. Endogenous cannabinoids, particularly the endocannabinoid AEA, play a crucial role in this system by inhibiting the function and proliferation of CD8+ T cells, affecting antitumor immunity. When you link all of them together, it’s what is known as the cannabinoid system, or the ECS for short. Research suggests that cannabinoids can help the ECS function at optimal levels.


What Are Cannabinoids?

Simply put, cannabinoids are the chemical compounds of the cannabis plant. They have been used extensively to treat symptoms such as pain and inflammation. They are gaining notoriety for their positive effects on the immune system. Additionally, cannabinoids interact with the central nervous system, influencing key brain areas like the hippocampus, cerebellum, and basal ganglia.

Cannabinoid receptors have a specific function in the brain and body. They can help regulate your moods, appetite, memory, and overall health. More importantly, they can also affect the overall function of the immune system. This is often referred to by scientists as “immuno-cannabinoid” modulation.

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box for medical marijuana as directed by a doctor for the treatment of marijuana


Cannabis and Immune Cells

The active components of cannabis are known to be immune modulators. Cannabis smoke, in particular, has been shown to impact respiratory health and immune response. They can tap into the immune system and alter its effects. For example, when you get a cut or strain a muscle, the immune system causes swelling in the area. Cannabis can suppress this system and basically tell it to calm down, affecting immune responses. Long-term marijuana use has also been associated with increased lung inflammation, pulmonary infection, and bronchitis.


THC and its Effects on T-Cell Immunity

Tetrahydrocannabinol (THC) is the primary psychoactive compound in cannabis, and it has a significant impact on the immune system, particularly on T-cell immunity. T cells are a type of immune cell that plays a crucial role in the adaptive immune response. They are like the elite soldiers of your immune system, trained to recognize and destroy specific pathogens.


Research has shown that THC can have immunosuppressive effects, meaning it can dampen the activity of these T cells. Specifically, THC has been found to inhibit T-cell proliferation and activation. This can impair the immune function, making it harder for your body to mount an effective immune response. As a result, individuals who consume THC may be more susceptible to infections and diseases.


Cannabinoids and their Impact on Immune Cell Proliferation

Cannabinoids, including both THC and cannabidiol (CBD), have been shown to affect the proliferation of immune cells. This means they can influence how quickly and effectively these cells multiply and respond to threats. Research indicates that cannabinoids can inhibit the proliferation of various immune cells, including T cells and B cells. This can lead to a weakened immune function and an increased risk of infections and diseases.

However, it’s not all bad news. Cannabinoids also possess anti-inflammatory effects, which can be beneficial in conditions characterized by excessive inflammation. For instance, in autoimmune diseases where the immune system attacks the body’s own tissues, the anti-inflammatory properties of cannabinoids can help to reduce symptoms and improve quality of life.


Anti Inflammatory Effects and the Immune System

You see when our bodies get infected by a virus or bacteria, the body’s natural response is inflammation. Cannabis smoking has been shown to impact the pulmonary immune response during viral infections, potentially increasing viral burden and dampening immune cell populations. This helps trap and isolate the damaged parts of the body. It also prevents the spread of infection.

However, sometimes the response goes crazy and becomes too inflamed. Recent research indicates that chronic inflammation is the source of:

●      Depression

●      Anxiety

●      Asthma

●      Arthritis

●      Allergies

●      Obesity

As a powerful anti-inflammatory, cannabis has been found to be useful for those suffering from health problems related to high levels of inflammation.


Autoimmune Disease

This is when inflammation prompts the body to attack itself. Smoking cannabis has been discussed in relation to its effects on the immune system, including potential impacts on autoimmune diseases. In these disorders, the immune system strikes the body’s organs, causes pain, and can even lead to death. These affect up to 50 million Americans and there are over 80 varieties of them. Some of them are:

●      Type 1 diabetes

●      Rheumatoid arthritis

●      Systemic lupus erythematosus

●      Celiac disease (sprue)

●      Inflammatory bowel diseases


Cannabis and Immune-Related Diseases

The Impact of Cannabis on Immune Function in HIV/AIDS Patients

Cannabis use among HIV/AIDS patients has been a subject of much research, revealing both potential benefits and risks. On the positive side, cannabis has been shown to have anti-inflammatory effects, which can help reduce inflammation and improve overall immune function. This can be particularly beneficial for HIV/AIDS patients, who often suffer from chronic inflammation.


However, there are also potential downsides. Cannabis use has been associated with impaired immune function in these patients, including reduced T-cell counts and impaired antibody production. This can make HIV/AIDS patients more susceptible to opportunistic infections and disease progression. Therefore, while cannabis may offer some benefits, it is crucial for HIV/AIDS patients to consult with their healthcare providers to carefully weigh the risks and benefits.


By understanding these complex interactions, we can make more informed decisions about cannabis use and its potential impact on our health.


Cannabis Boosts Immune Function

Research has found that the targeted use of cannabinoids can help boost the immune system.

●      Cannabis vs Inflammation – Recent research suggests that cannabis can help reduce inflammatory responses in patients. It has also been shown to play a critical role in helping conditions such as strokes and head injuries.

●      Cannabis vs Cancer – Early studies indicate that cannabis compounds can help kill off cancer cells. It triggers the self-destruct part of the immune response that tells a diseased cell to live or die.

●      Cannabis vs AIDS/HIV – These autoimmune diseases hijack the immune system and suppress it. This means that the body can’t fight off infection anymore. Preliminary research indicates that cannabis may actually improve immune function in patients with this disease.

●      Cannabis vs Diabetes Type 2 – The properties of cannabis can help improve the body’s metabolism and support insulin activity.

●      Cannabis Vs Inflammatory Bowel Diseases (IBD) –  Recent research suggests that cannabis helps support healthy gut activity.

●      Cannabis vs Fibromyalgia – Patients using cannabis experienced a reduction in pain after using CBD-rich cannabis.

●      Cannabis vs Celiac Disease – The compound THC helps to slow down the digestion and movement of food in the digestive tract while CBD helps against autoimmune attacks on the small intestine caused by gluten.


Purchase Cannabis Legally

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Bag with weed on a rustic wooden table

There are many variables to take into consideration when using cannabis to treat the immune system. Each strain has its own different properties and effects. Each delivery method has its own pros and cons.

This is why it’s so important to obtain your cannabis from licensed medical marijuana dispensaries (alternatively in Canada patients can opt to purchase from a federally Licensed Producer)! They will have advisors on hand who can advise you on the right strain to use, what dose to take, and how to consume it.


Conclusion

We hope you found this article useful. Did you know about all of the effects of cannabis on the immune system? Are there any that we missed or you’d like to know more about?  Let us know in the comments!

Oh, and don’t keep this information to yourself. Be sure to share this with your family and friends!

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